Here, the advantage for CPA over the other groups was 0. One participant was withdrawn three days after starting CPA having become depressed see above but this was not considered to be related to the intervention. In addition, dopamine antagonism may result in prolactin elevation, which may have an effect on libido Bancroft ; such drugs may also positively impact on mental disorders prevalent in this population e.
Recidivism data were compromised by the high rate of discontinuation. Three community studies did not formally report reoffending at all, focusing largely on 'abnormal sexual activity'. Anxiety data were not specifically collected and reported in Cooperbut investigators note a "dramatic anti aggressive effect" Cooperp similar to that reported in the literature, so providing evidence of "the tranquillising actions" of CPA Cooperp Allocation concealment We evaluated whether investigators and participants could foresee assignments before screening was complete and consent was given.
There are other limitations too. In Cooperthe authors reported that to compensate for missing data, appropriate corrections were made, and analysis of variance carried out.
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We judged the results for this outcome to be at high risk of bias given the significant dropout rate see below. Unclear: information on the blinding of assessors is unclear or unavailable from study authors. The review authors concluded that there were too few data to come to any conclusion about the effectiveness of MPA.
Anxiety; anger or aggression Data were not systematically reported but the investigators commented p that levels of anxiety and depression seemed high in the study, possibly due to participants' low mood as their court appearance approached, as well as due to other issues common amongst paedophiles, including alcohol and drug abuse.